Method validation for fatigue testing in kingpins

Fatigue Testing

Fatigue is the progressive, localized, permanent structural change that occurs in materials subjected to fluctuating stresses and strains that may result in cracks or fracture after a sufficient number of fluctuations. Fatigue fractures are caused by the simultaneous action of cyclic stress, tensile stress and plastic strain. If any one of these three is not present, fatigue cracking will not i...

Fatigue Device for Testing Ankle Joint Endoprostheses

The paper proposes a model of a fatigue device for testing dedicated to ankle prostheses. The concept of the testing device relies on two aspects: almost any type of ankle prosthesis can be tested on it and it has to work on INSTRON axial-torsion testing machine. Starting from these requirements, a 3D functional assembly that reproduces the real movement of the ankle joint during gait cycle has...

A New Method for Sperm Detection in Infertility Cure: Hypothesis Testing Based on Fuzzy Entropy Decision

In this paper, a new method is introduced for sperm detection in microscopic images for infertility treatment. In this method, firstly a hypothesis testing function is defined to separate sperms from plasma, non-sperm semen particles and noise. Then, some primary candidates are selected for sperms by watershed-based segmentation algorithm. Finally, candidates are either confirmed or rejected us...

Development and Validation of RP-HPLC-UV Method for Determination of Diclofenac Sodium Residues on Surfaces for Cleaning Validation

In recent years, cleaning validation has achieved a position of increasing in the pharmaceutical industry. It provides assurance to the cleaning procedure that ensures equipment is consistently cleaned from the product, detergent and microbial residues to an acceptable level to avoid cross-contamination and adulteration of drug product with other active ingredients. The aim of this study was to...

Testing For Efficiency Wages In Iran